Liver CellsThe four major cell types that are found in the liver are hepatocytes, stellate cells, sinusoidal endothelial cells and Kupffer cells.
Hepatocytes are the most numerous cells of the liver, represent 80% of the volume and about 60% by number. Their shape is multifaceted, with a number of areas ranging from six to twelve, their diameter ranges from 20 to 30 microns. They are often multinucleated and tetraploid, with the number of cores that can be up to four, a large nucleolus, rough and smooth endoplasmic reticulum well developed, numerous cisternae of Golgi, ribosomes, lysosomes, mitochondria, peroxisomes, which are both one of the cell types in which the organelles are more developed and presented, due to the high metabolic needs and the wide variety of tasks which they perform.
In a well-nourished body is not difficult to detect moderate amounts of glycogen and lipid vacuoles, or in the case of an overdose of iron, vacuoles or aggregates of ferritin and hemosiderin. The cytoplasm is eosinophilic background for the large number of mitochondria but with numerous basophilic granules due to the rough endoplasmic reticulum and ribosomes. You can find lipofuscin granules of golden-brown. The pole is fitted with sine dell epatocita many long and irregular microvilli on average 0.5 microns, the surface area alone is equal to 2 / 3 of the entire cell. Two adjacent hepatocytes form their plasma membranes with the bile canaliculi and are joined by tight junctions to prevent the entry of bile into the interstices, in the rest of the cell are the most common desmosomes and gap junctions. At the level of bile canaliculi accumulating numerous exocytosis of vesicles containing precisely to secrete bile into canaliculi.